Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417033 | 0.87 | MAPK14 (0.50) | MAPK14BRD4MAPK11DRD4 | |
| SCHEMBL1417255 | 0.83 | MAPK14 (0.56) | MAPK14KDM4EMAPK11NPC1DRD4 | |
| SCHEMBL1417031 | 0.81 | MAPK14 (0.51) | MAPK14MAPK11 | |
| SCHEMBL1417709 | 0.77 | MAPK14 (0.48) | MAPK14KDM4E | |
| SCHEMBL1417713 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11 | |
| SCHEMBL1417073 | 0.77 | SMYD3 (0.53) | MAPK14BRD4MAPK11 | |
| SCHEMBL1417371 | 0.76 | MAPK14 (0.48) | MAPK14MAPK11NPC1 | |
| SCHEMBL2218498 | 0.76 | MAPK14 (0.46) | MAPK14KDM4EMAPK11DRD4 | |
| SCHEMBL12729698 | 0.74 | MAPK14 (0.78) | MAPK14MAPK11 | |
| SCHEMBL452756 | 0.73 | MAPK14 (0.80) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298743-A1 | 5-membered heterocycle-based P38 kinase inhibitors | Novartis AG (CH) | 2011-03-23 | — | — | EP | claimed |