Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417033 | 0.87 | MAPK14 (0.50) | MAPK14MAPK11 | |
| SCHEMBL1417032 | 0.81 | MAPK14 (0.51) | MAPK14MAPK11 | |
| SCHEMBL1417371 | 0.76 | MAPK14 (0.48) | MAPK14MAPK11RIPK2 | |
| SCHEMBL1417073 | 0.75 | SMYD3 (0.53) | MAPK14MAPK11RIPK2 | |
| SCHEMBL1417201 | 0.74 | MAPK14 (0.58) | MAPK14MAPK11GRM5 | |
| SCHEMBL1416944 | 0.73 | MAPK14 (0.58) | MAPK14MAPK11 | |
| SCHEMBL1417713 | 0.73 | MAPK14 (0.48) | MAPK14MAPK11RIPK2 | |
| SCHEMBL1417709 | 0.73 | MAPK14 (0.48) | MAPK14RIPK2 | |
| SCHEMBL1383353 | 0.69 | MAPK14 (0.52) | MAPK14MAPK11GRM5 | |
| SCHEMBL27632955 | 0.69 | MAPK14 (0.60) | MAPK14RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298743-A1 | 5-membered heterocycle-based P38 kinase inhibitors | Novartis AG (CH) | 2011-03-23 | — | — | EP | claimed |