Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12936169 | 0.82 | MAPK14 (0.54) | MAPK14ALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL1417448 | 0.82 | MAPK14 (0.54) | MAPK14ALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL11965709 | 0.79 | MAPK14 (0.53) | MAPK14HTT | |
| SCHEMBL1417713 | 0.79 | MAPK14 (0.48) | MAPK14CYP3A4CYP2C9RIPK2 | |
| SCHEMBL1417073 | 0.79 | SMYD3 (0.53) | MAPK14MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL1417032 | 0.77 | MAPK14 (0.51) | MAPK14KDM4E | |
| SCHEMBL2212193 | 0.74 | MAPK14 (0.44) | MAPK14CYP3A4CYP2C9RIPK2 | |
| SCHEMBL1417033 | 0.74 | MAPK14 (0.50) | MAPK14 | |
| SCHEMBL1417371 | 0.74 | MAPK14 (0.48) | MAPK14KMT2ASMN1; SMN2HPGDRIPK2 | |
| SCHEMBL1417031 | 0.73 | MAPK14 (0.51) | MAPK14RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298743-A1 | 5-membered heterocycle-based P38 kinase inhibitors | Novartis AG (CH) | 2011-03-23 | — | — | EP | claimed |