Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14172008 | 0.83 | ACE (0.36) | ACE | |
| SCHEMBL14172000 | 0.82 | ACE (0.35) | ACE | |
| SCHEMBL14172007 | 0.82 | ACE (0.35) | ACE | |
| SCHEMBL14172005 | 0.80 | ACE (0.41) | ACE | |
| SCHEMBL14172012 | 0.80 | OPRM1 (0.39) | ACE | |
| SCHEMBL14172002 | 0.78 | ACE (0.35) | ACECYP11B2 | |
| SCHEMBL14171993 | 0.77 | XIAP (0.39) | ACE | |
| SCHEMBL14172004 | 0.77 | XIAP (0.41) | ACE | |
| SCHEMBL14171988 | 0.77 | ACE (0.37) | ACE | |
| SCHEMBL14171989 | 0.77 | ALOX15 (0.40) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390801-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2008-06-24 | — | — | US | disclosed |