Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678569 | 0.81 | — | — | |
| SCHEMBL719096 | 0.78 | ALDH1A1 (0.67) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL16341718 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL715302 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL719520 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL9323936 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL16341166 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL1311257 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL6074879 | 0.73 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRMEN1LMNA | |
| SCHEMBL6185698 | 0.73 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103467443-B | 2-alkyl-3-aminothiophene derivative and application thereof | MITSUI CHEMICALS AGRO INC | 2015-02-18 | — | — | CN | disclosed |
| CN-102395573-B | Process for producing 2-alkyl-3-aminothiophene derivative | MITSUI CHEMICALS AGRO INC | 2014-05-07 | — | — | CN | disclosed |
| CN-103467443-A | Process for production of 2-alkyl-3-aminothiophene derivative | MITSUI CHEMICALS AGRO INC | 2013-12-25 | — | — | CN | disclosed |
| CN-102395573-A | Process for producing 2-alkyl-3-aminothiophene derivative | MITSUI CHEMICALS AGRO INC | 2012-03-28 | — | — | CN | disclosed |
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | DNMT3B, DNMT1, DNMT3L | ALDH1A1 216/4885TDP1 213/4885TSHR 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.