⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174705 | 0.81 | ALDH1A1 (0.52) | — | |
| SCHEMBL16177524 | 0.78 | — | — | |
| SCHEMBL17936219 | 0.74 | CYP2D6 (0.41) | — | |
| SCHEMBL12122092 | 0.74 | ALDH1A1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL11231801 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL4303348 | 0.72 | HIF1A (0.44) | — | |
| SCHEMBL17936197 | 0.72 | MEN1 (0.39) | — | |
| SCHEMBL2052281 | 0.71 | — | — | |
| SCHEMBL3118936 | 0.71 | — | — | |
| SCHEMBL66347 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10987322-B2 | Immunoregulatory agents | FLEXUS BIOSCIENCES, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-20170112785-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES, INC. | 2017-04-27 | — | — | US | disclosed |
| EP-3151820-A1 | IMMUNOREGULATORY AGENTS | Flexus Biosciences, Inc. (US) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015188085-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES, INC. (US) | 2015-12-10 | — | — | WO | disclosed |
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
| EP-0296686-B1 | A PROCESS FOR THE PREPARATION OF CARBAMATES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1992-04-01 | — | — | EP | disclosed |
| EP-0296686-A1 | A process for the preparation of carbamates | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-12-28 | — | — | EP | disclosed |
| EP-0086281-B2 | PREPARATION OF CARBAMATES USING A PALLADIUM-CONTAINING CATALYST | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-10-19 | — | — | EP | disclosed |
| EP-0086281-B1 | PREPARATION OF CARBAMATES USING A PALLADIUM-CONTAINING CATALYST | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1985-05-15 | — | — | EP | disclosed |
| US-4474978-A | Preparation of carbamates | SHELL OIL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0086281-A1 | Preparation of carbamates using a palladium-containing catalyst | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1983-08-24 | — | — | EP | disclosed |