Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 6/20 | 0.40 |
| ▸ | CDK1 | P06493 | 6/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14175391 | 0.78 | ADORA2A (0.41) | ADORA2AADORA1 | |
| SCHEMBL14175398 | 0.75 | YTHDC1 (0.48) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL14175392 | 0.75 | ABCB11 (0.42) | — | |
| SCHEMBL14175402 | 0.73 | P2RY1 (0.47) | CCNB2CDK1CCNB1CCNB3PDE4A | |
| SCHEMBL5083628 | 0.71 | ADORA2A (0.49) | ADORA2AADORA1 | |
| SCHEMBL21755892 | 0.71 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL22166089 | 0.71 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL14175400 | 0.70 | P2RY1 (0.41) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL14175380 | 0.70 | CDK1 (0.41) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL5083559 | 0.69 | CDK1 (0.35) | CCNB2CDK1CCNB1CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |