Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 8/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9065521 | 0.99 | METAP1 (0.71) | METAP1CYP19A1SIGMAR1ACHE | |
| Hydrochloric Acid SCHEMBL7706188 | 0.86 | CYP19A1 (0.56) | METAP1CYP19A1SIGMAR1ACHE | |
| Hydrochloric Acid SCHEMBL2124625 | 0.84 | METAP1 (1.00) | METAP1ACHE | |
| Hydrochloric Acid SCHEMBL30772482 | 0.84 | METAP1 (1.00) | METAP1ACHE | |
| SCHEMBL2175676 | 0.83 | METAP1 (1.00) | METAP1CYP19A1ACHE | |
| SCHEMBL3033688 | 0.78 | CYP19A1 (0.77) | METAP1CYP19A1SIGMAR1ACHE | |
| Hydrochloric Acid SCHEMBL7703935 | 0.74 | DRD2 (0.51) | CYP19A1SIGMAR1 | |
| SCHEMBL866816 | 0.74 | METAP1 (0.67) | METAP1CYP19A1SIGMAR1ACHE | |
| SCHEMBL6270614 | 0.74 | METAP1 (0.71) | METAP1CYP19A1ACHE | |
| SCHEMBL6271181 | 0.74 | METAP1 (0.71) | METAP1CYP19A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378552-B2 | Monoamine re-uptake inhibitors and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-7378552-B2 | Monoamine re-uptake inhibitors and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-05-27 | — | — | US | disclosed |