Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | CCKAR | P32238 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049757 | 0.90 | IDO1 (0.44) | IDO1CCKARCCKBRCTSKPPARA | |
| SCHEMBL7160937 | 0.86 | IDO1 (0.43) | IDO1CCKARCCKBRCTSKPPARA | |
| SCHEMBL7363237 | 0.86 | CCKAR (0.44) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL7363235 | 0.83 | KLK5 (0.42) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL7166021 | 0.82 | ACE (0.47) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL7469657 | 0.81 | MAPT (0.44) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL7163527 | 0.80 | MAPT (0.46) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL7372914 | 0.80 | HSD17B10 (0.41) | IDO1CCKARCCKBRCTSKCTSL | |
| SCHEMBL8330384 | 0.79 | IDO1 (0.40) | IDO1CCKARCCKBRCTSKPOLB | |
| SCHEMBL4683912 | 0.79 | IDO1 (0.40) | IDO1CCKARCCKBRCTSKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371854-B2 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |
| US-7371854-B2 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | disclosed |