Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182706 | 1.00 | NPC1 (0.50) | NPC1RAB9AALDH1A1TP53PKM | |
| SCHEMBL14182636 | 0.91 | GRM4 (0.59) | NPC1RAB9AALDH1A1TP53PKM | |
| SCHEMBL14182630 | 0.91 | GRM4 (0.59) | NPC1RAB9AALDH1A1TP53PKM | |
| SCHEMBL14182639 | 0.91 | GRM4 (0.59) | NPC1RAB9AALDH1A1TP53PKM | |
| SCHEMBL14182677 | 0.91 | GRM4 (0.59) | NPC1RAB9AALDH1A1TP53PKM | |
| SCHEMBL14182718 | 0.87 | MAOA (0.57) | NPC1RAB9ANR2E3ITKSLC2A1 | |
| SCHEMBL14182737 | 0.87 | MAOA (0.54) | NPC1RAB9ANR2E3ITKSLC2A1 | |
| SCHEMBL14182716 | 0.87 | MAOA (0.54) | NPC1RAB9ANR2E3ITKSLC2A1 | |
| SCHEMBL14182634 | 0.86 | GRM4 (0.53) | NPC1RAB9AALDH1A1PKMGRM4 | |
| SCHEMBL14182698 | 0.86 | GRM4 (0.44) | NPC1RAB9AALDH1A1JAK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |