Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182668 | 1.00 | MAOA (0.42) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14183011 | 0.93 | ALDH1A1 (0.43) | GRM2ALDH1A1HPGDKDM4ETP53 | |
| SCHEMBL14182719 | 0.89 | MAOA (0.52) | MAOAMAOBALDH1A1HPGDKDM4E | |
| SCHEMBL14182657 | 0.87 | MAOA (0.55) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14182632 | 0.87 | MAOA (0.55) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14182651 | 0.87 | MAOA (0.55) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14182669 | 0.87 | MAOA (0.55) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14182642 | 0.87 | GRM2 (0.52) | GRM2ALDH1A1HPGDKDM4ETP53 | |
| SCHEMBL14182708 | 0.85 | MAOA (0.46) | MAOAMAOBGRM2ALDH1A1HPGD | |
| SCHEMBL14182697 | 0.84 | MAOA (0.61) | MAOAMAOBALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |