Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 3/20 | 0.53 |
| ▸ | CLK2 | P49760 | 5/20 | 0.51 |
| ▸ | CLK3 | P49761 | 5/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182700 | 1.00 | MAOA (0.56) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182626 | 1.00 | MAOA (0.56) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182914 | 0.92 | CLK2 (0.51) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182900 | 0.92 | CLK2 (0.51) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182712 | 0.90 | ALDH1A1 (0.47) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182732 | 0.90 | KCNK3 (0.61) | MAOAMAOBITKKCNK3KCNK9 | |
| SCHEMBL14182743 | 0.90 | KCNK3 (0.61) | MAOAMAOBITKKCNK3KCNK9 | |
| SCHEMBL14182710 | 0.90 | KCNK3 (0.61) | MAOAMAOBITKKCNK3KCNK9 | |
| SCHEMBL14182730 | 0.89 | TP53 (0.55) | MAOAMAOBITKCLK2CLK3 | |
| SCHEMBL14182631 | 0.89 | TP53 (0.55) | MAOAMAOBITKCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |