Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 6/20 | 0.52 |
| ▸ | CLK3 | P49761 | 6/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182899 | 1.00 | KDM4E (0.52) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182906 | 0.91 | GSK3A (0.52) | CLK2CLK3DYRK1AGSK3AGSK3B | |
| SCHEMBL14182696 | 0.90 | TP53 (0.55) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182730 | 0.90 | TP53 (0.55) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182749 | 0.90 | TP53 (0.55) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182631 | 0.90 | TP53 (0.55) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182900 | 0.90 | CLK2 (0.51) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14182914 | 0.90 | CLK2 (0.51) | KDM4ETP53CLK2CLK3DYRK1A | |
| SCHEMBL14183016 | 0.90 | KCNK3 (0.56) | CLK2CLK3DYRK1AITKMAOA | |
| SCHEMBL14182902 | 0.90 | KCNK3 (0.56) | CLK2CLK3DYRK1AITKMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |