Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | CLK3 | P49761 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182913 | 0.91 | KDM4E (0.52) | GSK3AGSK3BJAK2MAPKAPK2NAMPT | |
| SCHEMBL14182899 | 0.91 | KDM4E (0.52) | GSK3AGSK3BJAK2MAPKAPK2NAMPT | |
| SCHEMBL14182715 | 0.90 | RAB9A (0.50) | GSK3AGSK3BSMN1; SMN2CLK2CLK3 | |
| SCHEMBL14182734 | 0.90 | RAB9A (0.50) | GSK3AGSK3BSMN1; SMN2CLK2CLK3 | |
| SCHEMBL14182907 | 0.90 | ROCK2 (0.46) | GSK3BJAK2MAPKAPK2NAMPTCLK2 | |
| SCHEMBL14182846 | 0.90 | SLC2A1 (0.48) | JAK2MAPKAPK2 | |
| SCHEMBL14182847 | 0.86 | HDAC6 (0.47) | MAPKAPK2 | |
| SCHEMBL14182848 | 0.86 | KMT2A (0.50) | GSK3BMAPKAPK2 | |
| SCHEMBL14182712 | 0.85 | ALDH1A1 (0.47) | GSK3BJAK2NAMPTCLK2CLK3 | |
| SCHEMBL14182911 | 0.84 | VCP (0.51) | GSK3BSMN1; SMN2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |