Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 5/20 | 0.51 |
| ▸ | CLK3 | P49761 | 5/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182631 | 1.00 | TP53 (0.55) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182696 | 1.00 | TP53 (0.55) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182730 | 1.00 | TP53 (0.55) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182715 | 0.91 | RAB9A (0.50) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182734 | 0.91 | RAB9A (0.50) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182899 | 0.90 | KDM4E (0.52) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182913 | 0.90 | KDM4E (0.52) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182747 | 0.89 | MAOA (0.56) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182626 | 0.89 | MAOA (0.56) | TP53KDM4EMAOAMAOBITK | |
| SCHEMBL14182700 | 0.89 | MAOA (0.56) | TP53KDM4EMAOAMAOBITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |