Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14183014 | 1.00 | ITK (0.48) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14183008 | 1.00 | ITK (0.48) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14182669 | 0.92 | MAOA (0.55) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14182657 | 0.92 | MAOA (0.55) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14182651 | 0.92 | MAOA (0.55) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14182632 | 0.92 | MAOA (0.55) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14183003 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDTP53GRM2 | |
| SCHEMBL14182997 | 0.88 | PTPN1 (0.61) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14183001 | 0.88 | PTPN1 (0.61) | ITKPTPN1MAOAMAOBALDH1A1 | |
| SCHEMBL14182803 | 0.87 | ALDH1A1 (0.43) | ITKALDH1A1KDM4EHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |