Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5543076 | 0.89 | BCL2 (0.52) | BCL2DEGS1GSK3BDYRK1AGRIN2B | |
| SCHEMBL23193793 | 0.86 | BCL2 (0.48) | BCL2GSK3BDYRK1ACYP17A1 | |
| SCHEMBL29627265 | 0.86 | BCL2 (0.48) | BCL2GSK3BDYRK1ACYP17A1 | |
| SCHEMBL31378469 | 0.85 | BCL2 (0.49) | BCL2GSK3BDYRK1AKMT2AGRIN2B | |
| SCHEMBL31737264 | 0.85 | GSK3B (0.45) | BCL2GSK3BDYRK1AGRIN2BHDAC1 | |
| SCHEMBL5545025 | 0.85 | BCL2 (0.48) | BCL2DEGS1GSK3BDYRK1AGRIN2B | |
| SCHEMBL23166130 | 0.82 | CDK8 (0.50) | BCL2GSK3BDYRK1ACYP17A1 | |
| SCHEMBL3833158 | 0.82 | F10 (0.50) | BCL2GSK3BDYRK1AGRIN2BHDAC1 | |
| SCHEMBL12403311 | 0.81 | GSK3B (0.47) | BCL2GSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL21566049 | 0.81 | RAB9A (0.49) | BCL2GSK3BDYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368458-B2 | Bicyclic heterocycles as cannabinoid receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368458-B2 | Bicyclic heterocycles as cannabinoid receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-06 | — | — | US | disclosed |