Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.46 |
| ▸ | CTSG | P08311 | 4/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 4/20 | 0.46 |
| ▸ | CMA1 | P23946 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332252 | 0.80 | LMNA (0.47) | PRSS1CTSGCTRB1CMA1HPGD | |
| SCHEMBL834063 | 0.78 | PPARA (0.54) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL834064 | 0.78 | PPARA (0.54) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL10340094 | 0.78 | LMNA (0.45) | PRSS1CTSGCTRB1CMA1HPGD | |
| SCHEMBL31445909 | 0.77 | MAPT (0.39) | ADORA1HPGDRAB9AGAAMAPT | |
| SCHEMBL28190506 | 0.75 | LMNA (0.49) | PRSS1CTSGCTRB1CMA1HPGD | |
| SCHEMBL23921461 | 0.74 | ACE (0.58) | LMNAKMT2AMME | |
| SCHEMBL21777483 | 0.74 | ACE (0.58) | LMNAKMT2AMME | |
| SCHEMBL19751451 | 0.74 | HPGD (0.33) | ADORA1HPGDRAB9AGAAMAPT | |
| SCHEMBL12294114 | 0.73 | HPGD (0.59) | HPGDMAPTLMNAPOLBMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |