Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372213 | 0.93 | CA2 (0.52) | CA2SMN1; SMN2PTGS2ALDH1A1LMNA | |
| SCHEMBL16606256 | 0.90 | CSNK2A1 (0.49) | CA2SMN1; SMN2THRBPTGS2MAPK1 | |
| SCHEMBL18888242 | 0.86 | HDAC1 (0.49) | CA2SMN1; SMN2PTGS2ALDH1A1LMNA | |
| SCHEMBL31275634 | 0.84 | CA2 (0.71) | CA2SMN1; SMN2PTGS2ALDH1A1LMNA | |
| SCHEMBL31428 | 0.84 | CA2 (0.71) | CA2SMN1; SMN2PTGS2ALDH1A1LMNA | |
| SCHEMBL7791117 | 0.84 | SMN1; SMN2 (0.50) | CA2SMN1; SMN2THRBMAPK1ALDH1A1 | |
| SCHEMBL580037 | 0.84 | CA2 (0.50) | CA2SMN1; SMN2THRBMAPK1LMNA | |
| SCHEMBL13111719 | 0.84 | CA2 (0.50) | CA2SMN1; SMN2PTGS2MAPK1ALDH1A1 | |
| SCHEMBL12775553 | 0.84 | LDHA (0.51) | CA2SMN1; SMN2THRBMAPK1LMNA | |
| SCHEMBL12845579 | 0.82 | CSNK2A1 (0.42) | SMN1; SMN2THRBGAACSNK2A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075172-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |