Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405857 | 0.88 | ALDH1A1 (0.73) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL14202810 | 0.87 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL10674588 | 0.87 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL30168150 | 0.87 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL10629031 | 0.85 | MAPT (0.81) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL2072200 | 0.84 | ALDH1A1 (0.64) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL4490833 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL3271853 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL9819225 | 0.83 | ALDH1A1 (0.63) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL1285405 | 0.83 | HTT (0.74) | ALDH1A1MAPTL3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368467-B2 | Calcium channel modulators 2-(alkyl or (hetero)arylalkylthio)-imidazoles and S-oxides thereof; angina, hypertension, congestive heart failure, myocardial ischemia, arrhythmia, diabetes, urinary incontinence, stroke, pain, brain injury, or neuronal disorders | WYETH (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368467-B2 | Calcium channel modulators 2-(alkyl or (hetero)arylalkylthio)-imidazoles and S-oxides thereof; angina, hypertension, congestive heart failure, myocardial ischemia, arrhythmia, diabetes, urinary incontinence, stroke, pain, brain injury, or neuronal disorders | WYETH (US) | 2008-05-06 | — | — | US | disclosed |