Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.36 |
| ▸ | CDK9 | P50750 | 6/20 | 0.36 |
| ▸ | CDK1 | P06493 | 4/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17690308 | 0.89 | SRC (0.35) | CDK2CCNA2CCNE1CDK5CDK9 | |
| SCHEMBL14194717 | 0.84 | CDK2 (0.50) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL14194748 | 0.83 | CDK2 (0.44) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL14194754 | 0.74 | CDK2 (0.62) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL25255341 | 0.74 | — | — | |
| SCHEMBL14194739 | 0.73 | CDK2 (0.41) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL17690298 | 0.72 | CDK2 (0.37) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL17690303 | 0.71 | CDK2 (0.38) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL23508152 | 0.71 | EGLN1 (0.34) | CDK2CDK9CDK1CDK7CDK12 | |
| SCHEMBL30013417 | 0.71 | EGLN1 (0.34) | CDK2CDK9CDK1CDK7CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354921-B2 | Pyrazolotriazines as kinase inhibitors | SCHERING CORPORATION (US) | 2008-04-08 | — | — | US | disclosed |
| US-20070032495-A1 | Pyrazolotriazines as kinase inhibitors | MERCK SHARP & DOHME LLC | 2007-02-08 | — | — | US | disclosed |
| US-7166602-B2 | Pyrazolotriazines as kinase inhibitors | SCHERING CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032495-A1 | Pyrazolotriazines as kinase inhibitors | CDK2, CDK5, CDK1 | CDK2 1/4885CCNA2 92/4885CCNA1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.