Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.38 |
| ▸ | CDK9 | P50750 | 6/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CDK7 | P50613 | 3/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194717 | 0.86 | CDK2 (0.50) | CDK2CDK5CDK9CDK1CCNE1 | |
| SCHEMBL14194739 | 0.86 | CDK2 (0.41) | CDK2CDK5CDK9CDK1CCNE1 | |
| SCHEMBL14194734 | 0.80 | GSK3B (0.57) | CDK2CCNE1GSK3B | |
| SCHEMBL12953783 | 0.78 | GSK3B (0.48) | CDK2CDK5CDK9CDK1CCNE1 | |
| SCHEMBL14194765 | 0.77 | CDK2 (0.34) | CDK2CDK5CDK9CDK1CCNE1 | |
| SCHEMBL14194738 | 0.77 | GSK3B (0.41) | CDK2CDK5CDK9CCNE1GSK3B | |
| SCHEMBL18051077 | 0.77 | KCNN3 (0.47) | GSK3BHTT | |
| SCHEMBL14194733 | 0.77 | GHSR (0.39) | GSK3B | |
| SCHEMBL14194720 | 0.77 | GSK3B (0.41) | CDK2CDK5CDK9CCNE1GSK3B | |
| SCHEMBL14194768 | 0.75 | GSK3B (0.35) | CDK2CDK5CDK9CCNE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720883-B1 | PYRAZOLOTRIAZINES AS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-04-20 | — | — | EP | disclosed |