Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.35 |
| ▸ | ABL1 | P00519 | 9/20 | 0.35 |
| ▸ | FYN | P06241 | 3/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194752 | 0.89 | CDK2 (0.41) | SRCABL1FYNCDK5CDK5R1 | |
| SCHEMBL14194739 | 0.84 | CDK2 (0.41) | SRCABL1FYNCDK5CDK5R1 | |
| SCHEMBL17690298 | 0.82 | CDK2 (0.37) | SRCABL1FYNCDK5CDK5R1 | |
| SCHEMBL25255341 | 0.74 | — | — | |
| SCHEMBL14194717 | 0.73 | CDK2 (0.50) | SRCABL1FYNCDK5CDK5R1 | |
| SCHEMBL17690303 | 0.71 | CDK2 (0.38) | SRCABL1FYNCDK5CDK5R1 | |
| SCHEMBL14194748 | 0.71 | CDK2 (0.44) | SRCABL1CDK5CDK5R1CDK2 | |
| SCHEMBL23508152 | 0.71 | EGLN1 (0.34) | SRCABL1CDK2CDK9CDK7 | |
| SCHEMBL30013417 | 0.71 | EGLN1 (0.34) | SRCABL1CDK2CDK9CDK7 | |
| SCHEMBL25303402 | 0.69 | SCN2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720883-B1 | PYRAZOLOTRIAZINES AS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-04-20 | — | — | EP | disclosed |