Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267328 | 0.83 | CSF1R (0.68) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL14194083 | 0.80 | CYP3A4 (0.40) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL1267483 | 0.79 | CYP3A4 (0.54) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL14196170 | 0.78 | CSF1R (0.48) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL1267604 | 0.76 | CSF1R (0.71) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL14705849 | 0.76 | NTRK1 (0.49) | CSF1RKITHTR1ADRD1CYP3A4 | |
| SCHEMBL14197571 | 0.76 | NTRK1 (0.45) | CSF1RCYP2C19KITDRD1CYP3A4 | |
| SCHEMBL20376563 | 0.74 | NTRK1 (0.52) | KITHTR1ADRD1CYP3A4NTRK1 | |
| SCHEMBL12338615 | 0.72 | CSF1R (0.57) | CSF1RCYP2C19KITAURKBLCK | |
| SCHEMBL15316822 | 0.71 | CYP3A4 (0.44) | CSF1RCYP2C19KITCYP3A4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |