Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267604 | 0.89 | CSF1R (0.71) | CSF1RCYP2C19CYP3A4CYP2D6KIT | |
| SCHEMBL15316826 | 0.85 | LTA4H (0.42) | CSF1RCYP2C19CYP3A4CYP2D6HTR1A | |
| SCHEMBL12338611 | 0.84 | CSF1R (0.40) | CSF1RCYP2C19KITDRD1CYP1A2 | |
| SCHEMBL1267483 | 0.84 | CYP3A4 (0.54) | CSF1RCYP2C19CYP3A4CYP2D6KIT | |
| SCHEMBL12338612 | 0.84 | CSF1R (0.41) | CSF1RCYP2C19CYP3A4KITCYP1A2 | |
| SCHEMBL21304793 | 0.82 | CSF1R (0.59) | CSF1RCYP2C19CYP3A4CYP2D6KIT | |
| SCHEMBL1267328 | 0.82 | CSF1R (0.68) | CSF1RCYP2C19CYP3A4CYP2D6KIT | |
| SCHEMBL19302326 | 0.82 | CSF1R (0.58) | CSF1RCYP2C19CYP3A4CYP2D6KIT | |
| SCHEMBL15316822 | 0.78 | CYP3A4 (0.44) | CSF1RCYP2C19CYP3A4KITCYP2C9 | |
| SCHEMBL14197571 | 0.78 | NTRK1 (0.45) | CSF1RCYP2C19CYP3A4KITDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268858-B2 | e.g. 5-(3-methoxybenzyloxy)-1H-pyrrolo[2,3-b]pyridine; protein kinases inhibitor; central nervous system disorders; Alzheimer's disease; Parkinson's disease; anticancer, antitumor agents; analgesics; cogestive heart failure; skin disorders; inflammatory bowel disorders; transplant rejection | PLEXXIKON INC. (US) | 2012-09-18 | — | — | US | disclosed |