Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705849 | 0.89 | NTRK1 (0.49) | NTRK1CYP3A4KITLTA4HCSF1R | |
| SCHEMBL15316822 | 0.87 | CYP3A4 (0.44) | NTRK1CYP3A4KITLTA4HCSF1R | |
| SCHEMBL20376563 | 0.87 | NTRK1 (0.52) | NTRK1CYP3A4KITLTA4HNPC1 | |
| SCHEMBL1267483 | 0.83 | CYP3A4 (0.54) | NTRK1CYP3A4KITCSF1RDRD1 | |
| SCHEMBL1267328 | 0.81 | CSF1R (0.68) | NTRK1CYP3A4KITCSF1RDRD1 | |
| SCHEMBL15316826 | 0.78 | LTA4H (0.42) | CYP3A4LTA4HCSF1RCYP2C9CYP2C19 | |
| SCHEMBL12338615 | 0.78 | CSF1R (0.57) | CYP3A4KITLTA4HCSF1RDRD1 | |
| SCHEMBL14194083 | 0.77 | CYP3A4 (0.40) | NTRK1CYP3A4KITLTA4HCSF1R | |
| SCHEMBL14197570 | 0.77 | CSF1R (0.44) | CYP3A4CSF1RCYP2C9CYP2C19KDM4E | |
| SCHEMBL20037920 | 0.77 | NPC1 (0.60) | CYP3A4LTA4HNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |