Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 3/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196176 | 0.79 | CYP2C19 (0.44) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14197867 | 0.78 | CSF1R (0.53) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14196171 | 0.75 | CYP3A4 (0.35) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL13976951 | 0.73 | CYP2C19 (0.37) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14194976 | 0.72 | CSF1R (0.39) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14194180 | 0.72 | CYP3A4 (0.43) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14194348 | 0.71 | CSF1R (0.35) | CYP2C19CYP3A4CSF1RKITCYP2D6 | |
| SCHEMBL14197377 | 0.70 | PRKAB2 (0.38) | — | |
| SCHEMBL14194979 | 0.70 | — | — | |
| SCHEMBL14196177 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |