Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465906 | 0.75 | CCR2 (0.43) | PTGER2NQO2 | |
| SCHEMBL25321212 | 0.74 | KCNH2 (0.44) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL945801 | 0.73 | CYP1A2 (0.36) | CYP1A2CYP3A4CYP2D6PTGER2NQO2 | |
| SCHEMBL24915330 | 0.72 | HCRTR1 (0.40) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9902359 | 0.71 | CYP1A2 (0.33) | CYP1A2CYP3A4CYP2D6PTGER2NQO2 | |
| SCHEMBL17247586 | 0.70 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17963027 | 0.70 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4714316 | 0.69 | CYP1A2 (0.35) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4470267 | 0.69 | MEN1 (0.39) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1556569 | 0.69 | GPR119 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297144-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009146358-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |