Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 8/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060629 | 0.91 | CA12 (0.44) | GGPS1CA12CA1MMP2ACP3 | |
| SCHEMBL14199560 | 0.83 | GGPS1 (0.51) | GGPS1CA12CA1MMP2ACP3 | |
| SCHEMBL12257840 | 0.80 | GGPS1 (0.55) | GGPS1FDPS | |
| SCHEMBL14199554 | 0.75 | GGPS1 (0.47) | GGPS1ACP3FDPS | |
| SCHEMBL12060609 | 0.73 | GGPS1 (0.52) | GGPS1CA12CA1MMP2ACP3 | |
| SCHEMBL14199570 | 0.72 | GGPS1 (0.55) | GGPS1FDPS | |
| SCHEMBL14199553 | 0.71 | GGPS1 (0.75) | GGPS1FDPS | |
| SCHEMBL12257810 | 0.70 | GGPS1 (0.58) | GGPS1FDPS | |
| SCHEMBL14199561 | 0.70 | GGPS1 (0.44) | GGPS1FDPS | |
| SCHEMBL12048203 | 0.70 | FDPS (0.40) | GGPS1CA12CA1MMP2ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |