Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CCR10 | P46092 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14199602 | 0.87 | KMT2A (0.57) | KMT2AKDM4ECYP2D6CCR10CYP2C19 | |
| SCHEMBL14160600 | 0.86 | KMT2A (0.68) | KMT2AMEN1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14199615 | 0.85 | KMT2A (0.55) | KMT2AKDM4ECYP2D6MEN1CASP2 | |
| SCHEMBL11352268 | 0.85 | KMT2A (0.64) | KMT2AHSD17B10CYP2D6MEN1CYP2C19 | |
| SCHEMBL14199611 | 0.84 | KMT2A (0.54) | KMT2AKDM4ECYP2D6MEN1CCR10 | |
| Hydrochloric Acid SCHEMBL11376105 | 0.84 | KMT2A (0.63) | KMT2AHSD17B10CYP2D6MEN1CYP2C19 | |
| Pimonidazole SCHEMBL51977 | 0.84 | KMT2A (0.63) | KMT2AHSD17B10CYP2D6MEN1CYP2C19 | |
| SCHEMBL11350118 | 0.83 | KMT2A (0.60) | KMT2AKDM4ECYP2D6MEN1CCR10 | |
| Pimonidazole SCHEMBL11390660 | 0.83 | KMT2A (0.62) | KMT2AHSD17B10CYP2D6MEN1CYP2C19 | |
| SCHEMBL8895819 | 0.82 | KMT2A (0.67) | KMT2AHSD17B10CYP2D6MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056136-B2 | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia | NATURAL PHARMACIA INTERNATIONAL, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-20080085237-A1 | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085237-A1 | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia | HIF1A, HIF1AN, NME4 | KMT2A 506/4885KDM4E 615/4885HSD17B10 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.