SCHEMBL142000

SCHEMBL142000

COC(=O)c1ccc(C(=O)Oc2ccc(C(C)(C)c3ccc(OC)c(C)c3)cc2C)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.56
KMT2A Q03164 5/20 0.55
LMNA P02545 2/20 0.45
HPGD P15428 1/20 0.45
MEN1 O00255 3/20 0.45
TDP1 Q9NUW8 1/20 0.44
MGLL Q99685 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
ALDH1A1 P00352 2/20 0.43
PKM P14618 1/20 0.43
HTT P42858 1/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13657601 0.94 MAPT (0.53) MAPTKMT2ALMNAHPGDMEN1
SCHEMBL16775317 0.92 KMT2A (0.47) MAPTKMT2ALMNAHPGDMEN1
SCHEMBL12637532 0.92 MAPT (0.49) MAPTKMT2ALMNAHPGDMEN1
SCHEMBL12345970 0.90 KMT2A (0.46) MAPTKMT2AMEN1TDP1ALDH1A1
SCHEMBL2743140 0.89 KMT2A (0.49) MAPTKMT2AHPGDMEN1TDP1
SCHEMBL13865039 0.88 MAPT (0.46) MAPTKMT2ALMNAMEN1TDP1
SCHEMBL12445348 0.87 KMT2A (0.43) MAPTKMT2ATDP1ALDH1A1
SCHEMBL13304675 0.87 MAPT (0.51) MAPTKMT2AHPGDMEN1TDP1
SCHEMBL13253555 0.86 MAPT (0.50) MAPTKMT2ALMNAHPGDMEN1
SCHEMBL14508990 0.86 MAPT (0.47) MAPTKMT2ALMNAMEN1MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180024449-A1 PHOTORECEPTOR FOR ELECTROPHOTOGRAPHY, METHOD FOR MANUFACTURING THE SAME, AND ELECTROPHOTOGRAPHIC DEVICE FUJI ELECTRIC CO., LTD. (JP) 2018-01-25 US disclosed
US-8404414-B2 Electrophotographic photoconductor and manufacturing method thereof FUJI ELECTRIC CO., LTD. (JP) 2013-03-26 US disclosed
US-20120058422-A1 PHOTORECEPTOR FOR ELECTROPHOTOGRAPHY, PROCESS FOR PRODUCING THE SAME, AND ELECTROPHOTOGRAPHIC APPARATUS FUJI ELECTRIC CO., LTD (JP) 2012-03-08 US disclosed
US-20110189603-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND MANUFACTURING METHOD THEREOF FUJI ELECTRIC SYSTEMS CO., LTD. (JP) 2011-08-04 US disclosed