SCHEMBL13657601

SCHEMBL13657601

COC(=O)c1cccc(C(=O)Oc2ccc(C(C)(C)c3ccc(OC(=O)c4ccc(C(=O)Oc5ccc(C(C)(C)c6ccc(OC)c(C)c6)cc5C)cc4)c(C)c3)cc2C)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.53
KMT2A Q03164 5/20 0.52
MEN1 O00255 4/20 0.43
RAB9A P51151 2/20 0.43
NPC1 O15118 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MGLL Q99685 1/20 0.42
P4HB P07237 1/20 0.41
LMNA P02545 2/20 0.41
HPGD P15428 1/20 0.41
SLC6A3 Q01959 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PRSS1 P07477 1/20 0.40
ACR P10323 1/20 0.40
ALDH1A1 P00352 2/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL142000 0.94 MAPT (0.56) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL14508990 0.93 MAPT (0.47) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL14007585 0.92 MAPT (0.43) MAPTKMT2AMEN1SMN1; SMN2HPGD
SCHEMBL12376992 0.92 MAPT (0.43) MAPTKMT2AMEN1SMN1; SMN2LMNA
SCHEMBL12574843 0.90 MAPT (0.46) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL142010 0.89 KMT2A (0.43) MAPTKMT2AMEN1RAB9ASMN1; SMN2
SCHEMBL2743140 0.89 KMT2A (0.49) MAPTKMT2AMEN1SMN1; SMN2HPGD
SCHEMBL12404394 0.87 KMT2A (0.44) MAPTKMT2AMEN1NPC1SMN1; SMN2
SCHEMBL19500466 0.86 MAPT (0.43) MAPTKMT2AMEN1NPC1SMN1; SMN2
SCHEMBL12637532 0.86 MAPT (0.49) MAPTKMT2AMEN1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7608372-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and processing cartridge KONICA MINOLTA BUSINESS TECHNOLOGIES, INC (JP) 2009-10-27 US disclosed