SCHEMBL12445348

SCHEMBL12445348

COc1ccc(C(C)(C)c2ccc(OC(=O)c3ccc(-c4ccc(C(C)=O)cc4)cc3)c(C)c2)cc1C

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.43
MAPT P10636 6/20 0.42
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
HAVCR2 Q8TDQ0 1/20 0.39
TP53 P04637 1/20 0.39
GLA P06280 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12345970 0.96 KMT2A (0.46) KMT2AMAPTALDH1A1GAATDP1
SCHEMBL14007585 0.90 MAPT (0.43) KMT2AMAPTKDM4EALDH1A1GAA
SCHEMBL12404390 0.90 KMT2A (0.47) KMT2AMAPTALDH1A1GAATDP1
SCHEMBL12376959 0.90 KMT2A (0.47) KMT2AMAPTALDH1A1GAATDP1
SCHEMBL12762439 0.89 HPGD (0.44) KMT2AMAPTALDH1A1GAATP53
SCHEMBL18591532 0.88 KMT2A (0.40) KMT2AMAPTKDM4EALDH1A1GAA
SCHEMBL12376992 0.88 MAPT (0.43) KMT2AMAPTKDM4EALDH1A1GAA
SCHEMBL142000 0.87 MAPT (0.56) KMT2AMAPTALDH1A1TDP1
SCHEMBL16775317 0.87 KMT2A (0.47) KMT2AMAPTKDM4EALDH1A1HAVCR2
SCHEMBL19500472 0.86 MAPT (0.44) KMT2AMAPTKDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8865380-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2014-10-21 US disclosed
US-20110177438-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-07-21 US disclosed
US-7901855-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2011-03-08 US disclosed
US-7875410-B2 capable opersistently exerting effect of mitigating contact stress with contact members and improved potential stability during repeated use; polycarbonates CANON KABUSHIKI KAISHA (JP) 2011-01-25 US disclosed
US-20100092208-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2010-04-15 US disclosed
US-20100092209-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2010-04-15 US disclosed