Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200312 | 0.91 | HTR1A (0.42) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL14229118 | 0.89 | L3MBTL1 (0.52) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL14230000 | 0.85 | TACR1 (0.49) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL8913882 | 0.84 | TACR1 (0.57) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL8376444 | 0.75 | TACR1 (0.49) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11506406 | 0.74 | HTR1A (0.67) | TACR1TDP1SIGMAR1HTR1ACA12 | |
| SCHEMBL11228139 | 0.74 | TACR1 (0.40) | TACR1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL8014785 | 0.73 | TACR1 (0.65) | TACR1HTR1ACA12CA1CA9 | |
| SCHEMBL14200263 | 0.73 | CNR2 (0.46) | L3MBTL1SIGMAR1CA12CA1CA9 | |
| SCHEMBL8605252 | 0.72 | POLB (0.60) | TACR1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |