Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 3/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201067 | 0.98 | CA12 (0.44) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL28545566 | 0.96 | CA12 (0.44) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14201275 | 0.96 | CA12 (0.48) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14201114 | 0.92 | CA12 (0.41) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14201288 | 0.92 | SIGMAR1 (0.46) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14518993 | 0.91 | DNM1 (0.43) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14543501 | 0.89 | CA12 (0.46) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14518989 | 0.89 | CA12 (0.40) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14518994 | 0.89 | DNM1 (0.47) | CA12CA1CA9MMP1MMP2 | |
| SCHEMBL14201251 | 0.88 | CA12 (0.52) | CA12CA1CA9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |