Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CES1 | P23141 | 5/20 | 0.31 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200358 | 0.98 | CNR2 (0.40) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14200349 | 0.95 | CNR2 (0.39) | CNR2CA1 | |
| SCHEMBL14200354 | 0.89 | CNR2 (0.38) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14200353 | 0.89 | CA1 (0.39) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14200363 | 0.88 | FAAH (0.38) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14200355 | 0.88 | CNR2 (0.40) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14201273 | 0.88 | FAAH (0.38) | CNR2FAAHCA2CES1CES2 | |
| SCHEMBL14200218 | 0.84 | CNR2 (0.39) | CNR2CA1 | |
| SCHEMBL14201305 | 0.84 | CA1 (0.40) | CNR2CA2CA1 | |
| SCHEMBL14200434 | 0.83 | CA2 (0.33) | CNR2FAAHCA2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |