Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200817 | 1.00 | MAOA (0.49) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200950 | 0.94 | ADORA2A (0.44) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200962 | 0.93 | CYP1A2 (0.45) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200811 | 0.93 | CASP3 (0.43) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200944 | 0.90 | MAOA (0.41) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200924 | 0.86 | KDM4E (0.38) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200946 | 0.84 | MAPT (0.43) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200867 | 0.84 | MAPT (0.38) | MAOACYP1A2MAPTKDM4EMAPK1 | |
| SCHEMBL14200935 | 0.84 | POLB (0.48) | MAOACYP1A2MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL14200933 | 0.80 | MAPT (0.46) | CYP1A2MAPTKDM4EMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354947-B2 | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354947-B2 | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-04-08 | — | — | US | disclosed |