Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 12/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735387 | 0.82 | ERN1 (0.51) | ERN1LMNARAF1BRAFALDH1A1 | |
| SCHEMBL26070197 | 0.79 | PDE10A (0.48) | ERN1LMNARAF1BRAFALDH1A1 | |
| SCHEMBL8325220 | 0.77 | ERN1 (0.64) | ERN1LMNARAF1BRAFALDH1A1 | |
| SCHEMBL4734973 | 0.77 | ERN1 (0.69) | ERN1KDM4EMAPT | |
| SCHEMBL3252986 | 0.75 | ERN1 (0.66) | ERN1LMNAALDH1A1KDM4ETSHR | |
| SCHEMBL6092630 | 0.75 | PIK3CD (0.58) | ERN1RAF1BRAFALDH1A1KDM4E | |
| SCHEMBL4729694 | 0.75 | DYRK1A (0.55) | ERN1LMNARAF1BRAFALDH1A1 | |
| SCHEMBL4600135 | 0.74 | ALDH1A1 (0.62) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL7055331 | 0.74 | ERN1 (0.51) | ERN1LMNARAF1BRAFALDH1A1 | |
| SCHEMBL12678662 | 0.73 | ERN1 (0.50) | ERN1LMNARAF1BRAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057469-A1 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |