Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.51 |
| ▸ | ERN1 | O75460 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29377512 | 0.83 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL4600135 | 0.77 | ALDH1A1 (0.62) | ERN1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8502285 | 0.76 | PDGFRB (0.79) | PDGFRBPDGFRA | |
| SCHEMBL12427765 | 0.76 | ERN1 (0.56) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL4735387 | 0.75 | ERN1 (0.51) | PDGFRBPDGFRAERN1RAF1BRAF | |
| SCHEMBL14203756 | 0.75 | ERN1 (0.51) | ERN1RAF1BRAFKDM4EMEN1 | |
| SCHEMBL3012534 | 0.74 | PDGFRB (0.65) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL183330 | 0.73 | PIK3CA (1.00) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL2473569 | 0.73 | PDGFRB (0.50) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL7055331 | 0.73 | ERN1 (0.51) | ERN1CLK4RAF1BRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | PIK3CD 397/4885PIK3CA 293/4885PIK3CB 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.