Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 13/20 | 0.69 |
| ▸ | ERCC5 | P28715 | 8/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208537 | 0.86 | FEN1 (0.60) | FEN1ERCC5TP53KDM4E | |
| SCHEMBL5113290 | 0.84 | FEN1 (0.84) | FEN1ERCC5KCNH2 | |
| SCHEMBL5113032 | 0.83 | FEN1 (0.66) | FEN1ERCC5TP53KCNH2 | |
| SCHEMBL20864156 | 0.82 | FEN1 (1.00) | FEN1ERCC5 | |
| SCHEMBL5107928 | 0.80 | FEN1 (0.64) | FEN1ERCC5TP53KCNH2 | |
| SCHEMBL14208497 | 0.79 | FEN1 (0.52) | FEN1ERCC5TP53KDM4E | |
| SCHEMBL27703603 | 0.76 | FEN1 (0.75) | FEN1ERCC5 | |
| SCHEMBL5104130 | 0.76 | FEN1 (0.59) | FEN1ERCC5TP53KDM4EKCNH2 | |
| SCHEMBL14208517 | 0.75 | FEN1 (0.51) | FEN1ERCC5TP53KDM4E | |
| SCHEMBL14208516 | 0.74 | FEN1 (0.49) | FEN1ERCC5TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | MIF, MMP12, MSR1 | FEN1 2495/4885ERCC5 4724/4885TP53 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.