Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273 | 0.84 | BACE1 (0.41) | BACE1ABL1CTSD | |
| SCHEMBL13879 | 0.78 | BACE1 (0.44) | BACE1ABL1 | |
| SCHEMBL14321428 | 0.76 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14321509 | 0.76 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14321508 | 0.76 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14321506 | 0.76 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14321669 | 0.74 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL14321666 | 0.74 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL14321664 | 0.74 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL14321668 | 0.74 | BACE1 (0.56) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |