Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14210 | 0.84 | BACE1 (0.41) | BACE1ABL1CTSD | |
| SCHEMBL13879 | 0.81 | BACE1 (0.44) | BACE1ABL1 | |
| SCHEMBL9849 | 0.73 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14322046 | 0.73 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL9848 | 0.73 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14322043 | 0.73 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL13664 | 0.66 | BACE1 (0.57) | BACE1ABL1CTSD | |
| SCHEMBL13984 | 0.65 | GRM5 (0.39) | BACE1 | |
| SCHEMBL9283 | 0.64 | BACE1 (0.74) | BACE1 | |
| SCHEMBL14321877 | 0.64 | BACE1 (0.74) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |