Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273 | 0.81 | BACE1 (0.41) | BACE1ABL1 | |
| SCHEMBL14210 | 0.78 | BACE1 (0.41) | BACE1ABL1 | |
| SCHEMBL9177 | 0.75 | BACE1 (0.76) | BACE1 | |
| SCHEMBL14321887 | 0.75 | BACE1 (0.76) | BACE1 | |
| SCHEMBL9869 | 0.74 | BACE1 (0.80) | BACE1 | |
| SCHEMBL13984 | 0.71 | GRM5 (0.39) | BACE1 | |
| SCHEMBL13664 | 0.63 | BACE1 (0.57) | BACE1ABL1 | |
| SCHEMBL14324803 | 0.62 | BACE1 (0.83) | BACE1 | |
| SCHEMBL11567 | 0.62 | BACE1 (0.83) | BACE1 | |
| SCHEMBL21739921 | 0.61 | EPHX1 (0.49) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |