Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420890 | 0.85 | KIF11 (0.39) | IDO1BACE1BACE2 | |
| SCHEMBL1421185 | 0.85 | AAK1 (0.35) | BRAFAAK1LCKBACE1CYP17A1 | |
| SCHEMBL1420964 | 0.84 | BACE1 (0.39) | BRAFAAK1BACE1BACE2 | |
| SCHEMBL1420814 | 0.82 | BACE1 (0.35) | BRAFIDO1AAK1LCKBACE1 | |
| SCHEMBL1421023 | 0.82 | BACE1 (0.38) | BRAFIDO1AAK1LCKBACE1 | |
| SCHEMBL1420822 | 0.81 | ACVR1B (0.36) | BRAFBACE1CYP17A1RORCBACE2 | |
| SCHEMBL3177587 | 0.78 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL3177593 | 0.78 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL3187951 | 0.74 | BRAF (0.34) | BRAFIDO1AAK1BACE1CYP17A1 | |
| SCHEMBL1420877 | 0.72 | BACE1 (0.43) | BACE1CYP17A1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297120-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009134617-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2009-11-05 | — | — | WO | disclosed |