Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 16/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14211170 | 0.95 | CNR1 (0.86) | CNR1CYP2C9CYP2C19CYP3A4PTGS2 | |
| SCHEMBL14541009 | 0.92 | CNR1 (0.79) | CNR1CYP2C9CYP2C19CYP3A4NR3C1 | |
| SCHEMBL14211892 | 0.92 | CNR1 (0.91) | CNR1CYP2C9CYP2C19CYP3A4NR3C1 | |
| SCHEMBL14212433 | 0.91 | CNR1 (0.84) | CNR1CYP2C9CYP2C19CYP3A4PTGS2 | |
| SCHEMBL14212429 | 0.90 | CNR1 (0.79) | CNR1CYP2C9CYP2C19CYP3A4NR3C1 | |
| SCHEMBL14211056 | 0.90 | CNR1 (0.73) | CNR1CYP2C9CYP2C19CYP3A4PTGS2 | |
| SCHEMBL14211169 | 0.90 | CNR1 (0.78) | CNR1CYP2C9CYP2C19CYP3A4NR3C1 | |
| SCHEMBL14211055 | 0.89 | CNR1 (0.75) | CNR1CYP2C9CYP2C19CYP3A4PTGS2 | |
| SCHEMBL14211166 | 0.89 | CNR1 (0.80) | CNR1CYP2C9CYP2C19CYP3A4NR3C1 | |
| SCHEMBL14212430 | 0.89 | CNR1 (0.82) | CNR1CYP2C9CYP2C19CYP3A4PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378418-B2 | Azabicyclic heterocycles as cannabinoid receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| EP-1697370-B1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-04-25 | — | — | EP | disclosed |