Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2608841 | 0.81 | TSHR (0.42) | NUDT1ALDH1A1TSHRSMN1; SMN2KMT2A | |
| SCHEMBL13012202 | 0.79 | SMN1; SMN2 (0.50) | NUDT1ALDH1A1TSHRSMN1; SMN2KMT2A | |
| SCHEMBL18480437 | 0.73 | CDK1 (0.35) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL13256151 | 0.72 | CYP1A2 (0.42) | NUDT1TSHRKMT2ALMNAMAPT | |
| SCHEMBL13064187 | 0.72 | MAPT (0.53) | NUDT1ALDH1A1TSHRSMN1; SMN2KMT2A | |
| SCHEMBL13020442 | 0.70 | NUDT1 (0.69) | NUDT1ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL1421836 | 0.68 | SMN1; SMN2 (0.42) | ALDH1A1TP53SMN1; SMN2LMNAMAPT | |
| SCHEMBL19890949 | 0.68 | MAPT (0.48) | NUDT1ALDH1A1TSHRSMN1; SMN2KMT2A | |
| Propane SCHEMBL10851739 | 0.68 | SMN1; SMN2 (0.41) | NUDT1ALDH1A1TSHRTP53CYP3A4 | |
| Propane SCHEMBL10852102 | 0.68 | SMN1; SMN2 (0.41) | NUDT1ALDH1A1TSHRTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309773-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309773-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | JAK2, JAK1, JAK3 | NUDT1 1037/4885CDK1 164/4885CCNB1 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.