Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.77 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | CDK9 | P50750 | 5/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214739 | 0.90 | TEK (0.82) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6598236 | 0.84 | TEK (0.73) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6479686 | 0.81 | TEK (0.89) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6480366 | 0.81 | TEK (0.76) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6478685 | 0.81 | TEK (0.76) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6478261 | 0.80 | TEK (1.00) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6492448 | 0.80 | TEK (0.75) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214552 | 0.80 | TEK (0.81) | TEKKDRFGFR3FGFR2FGFR1 | |
| SCHEMBL14214554 | 0.80 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214551 | 0.78 | TEK (0.78) | TEKKDRFGFR3FGFR2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |