Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK9 | P50750 | 4/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214549 | 0.84 | TEK (0.77) | TEKKDRFGFR3FGFR2CCNT1 | |
| SCHEMBL6480366 | 0.84 | TEK (0.76) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL6492448 | 0.83 | TEK (0.75) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL14214554 | 0.83 | TEK (0.74) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL14214739 | 0.82 | TEK (0.82) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL6478685 | 0.82 | TEK (0.76) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL14214552 | 0.81 | TEK (0.81) | TEKKDRFGFR3FGFR2FGFR1 | |
| SCHEMBL6479686 | 0.81 | TEK (0.89) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL6480986 | 0.80 | TEK (0.74) | TEKKDRFGFR3FGFR2PTK2 | |
| SCHEMBL6486793 | 0.78 | TEK (0.82) | TEKKDRFGFR3FGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |