Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.82 |
| ▸ | KDR | P35968 | 2/20 | 0.78 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.64 |
| ▸ | IGF1R | P08069 | 4/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214549 | 0.90 | TEK (0.77) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6478261 | 0.88 | TEK (1.00) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6479686 | 0.84 | TEK (0.89) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6480366 | 0.84 | TEK (0.76) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6478685 | 0.84 | TEK (0.76) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6492448 | 0.83 | TEK (0.75) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214552 | 0.83 | TEK (0.81) | TEKKDRFGFR3FGFR2FGFR1 | |
| SCHEMBL6598236 | 0.82 | TEK (0.73) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214551 | 0.81 | TEK (0.78) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214554 | 0.81 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |