Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.84 |
| ▸ | LCK | P06239 | 4/20 | 0.84 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.84 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.60 |
| ▸ | MTOR | P42345 | 10/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214609 | 0.91 | KDR (0.87) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6480028 | 0.87 | KDR (0.77) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6478730 | 0.87 | KDR (0.77) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6478410 | 0.87 | KDR (0.80) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214615 | 0.86 | KDR (0.85) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214730 | 0.86 | KDR (0.82) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214612 | 0.84 | KDR (0.82) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6489956 | 0.84 | KDR (0.81) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6487158 | 0.83 | KDR (0.73) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6492447 | 0.83 | KDR (0.73) | KDRLCKMAPK14PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |